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Publications from Graduate School
18. Narayanan, A.; Dhinojwala, A.; Joy, A. Design Principles for Creating Synthetic Underwater Adhesives. Chem. Soc. Rev. 2021, in press.
17. Patil, R.; Sancaktar, E.; Narayanan, A.; Tantisuwanno, C. Polyimide-Polyacrylic Acid Smart Membranes Fabricated Using 248 nm KrF. Biointerface Research in Applied Chemistry 2021, in press.
16. Tseng, Y.-T.; Narayanan, A.; Mishra, K.; Liu, X.; Joy, A. Light-Activated Adhesion and Debonding of Underwater Pressure Sensitive Adhesives. ACS Appl. Mater. Interfaces 2021, 13, 29048.
Adhesives that can be peeled off with out effort is desired in band-aids designed for patients with pain intolerance and chronic wounds. To address this need, in this study, we created underwater adhesives that can show 80% reduction in adhesion when exposed to light. Some of formulations can also increase adhesion strength when exposed to light.
Adhesives that can be peeled off with out effort is desired in band-aids designed for patients with pain intolerance and chronic wounds. To address this need, in this study, we created underwater adhesives that can show 80% reduction in adhesion when exposed to light. Some of formulations can also increase adhesion strength when exposed to light.
15. Narayanan, A.#; Kaur, S.#; Kumar, N.; Joy, A.; Dhinojwala, A. Cooperative Multivalent Weak and Strong Interfacial Interactions Enhance the Adhesion of Mussel-Inspired Adhesives. Macromolecules 2021, 54, 5417.
The interfacial interactions of the amino acid sequences in the mussel foot proteins help mussels to stick underwater. However, the roles of specific interactions at the interface remain unknown. In this study, we revealed the role of weak (aromatic-OH) and strong (hydrogen bonds) in determining the effective strength of synthetic mussel-inspired adhesives using tailored chemistry, interfacial adhesion measurements, sum-frequency generation spectroscopy, and MD simulations.
The interfacial interactions of the amino acid sequences in the mussel foot proteins help mussels to stick underwater. However, the roles of specific interactions at the interface remain unknown. In this study, we revealed the role of weak (aromatic-OH) and strong (hydrogen bonds) in determining the effective strength of synthetic mussel-inspired adhesives using tailored chemistry, interfacial adhesion measurements, sum-frequency generation spectroscopy, and MD simulations.
14. Narayanan, A.; Menefee, J. R.; Liu, Q.; Dhinojwala, A.; Joy, A. Lower Critical Solution Temperature-Driven SelfCoacervation of Non-Ionic Polyester Underwater Adhesives. ACS Nano 2020, 14, 8359.
Coacervation/liquid-liquid phase separation is nature's mechanism to stick underwater. For example, mussels and sandcastle worms uses phase separating proteins to adhere substrates underwater. Herein, we mimic the coacervation using synthetic polymers that are devoid of charged species. The dense phase formed from the phase separation creates strong underwater adhesive.
The study was highlighted by Chemical and Engineering News (C&EN) "Mussel-Inspired Polymer Glue Sticks to Wet Surfaces"
Coacervation/liquid-liquid phase separation is nature's mechanism to stick underwater. For example, mussels and sandcastle worms uses phase separating proteins to adhere substrates underwater. Herein, we mimic the coacervation using synthetic polymers that are devoid of charged species. The dense phase formed from the phase separation creates strong underwater adhesive.
The study was highlighted by Chemical and Engineering News (C&EN) "Mussel-Inspired Polymer Glue Sticks to Wet Surfaces"
13. Narayanan, A.; Xu, Y.; Dhinojwala, A.; Joy, A. Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers. ChemEngineering 2020, 4, 32
Tissue adhesives are projected to be an essential toolkit in the surgeons box. A history of photoreactive tissue adhesives (1995-2020), their photochemistry and adhesive mechanisms are reviewed.
Tissue adhesives are projected to be an essential toolkit in the surgeons box. A history of photoreactive tissue adhesives (1995-2020), their photochemistry and adhesive mechanisms are reviewed.
12. Liu, Q.; Jain, T.; Peng, C.; Peng, F.; Narayanan, A.; Joy, A. Introduction of Hydrogen Bonds Improves the Shape Fidelity of Viscoelastic 3D Printed Scaffolds While Maintaining Their Low Temperature Printability. Macromolecules 2020, 53, 3690.
Introduction of hydrogen bonds to the molecular structure of 3D-printable inks provided high shape fidelity to the 3D scaffolds.
Introduction of hydrogen bonds to the molecular structure of 3D-printable inks provided high shape fidelity to the 3D scaffolds.
11. Jain, T.; Clay, W.; Tseng, Y.-M.; Vishwakarma, A.; Narayanan, A.; Ortiz, D.; Liu, Q.; Joy, A. Role of pendant side-chain length in determining 3D printability. Polym. Chem. 2019, 10, 5543.
3D printable inks were created from degradable polymers. Near-room temperature melting point allows high resolution printing.
3D printable inks were created from degradable polymers. Near-room temperature melting point allows high resolution printing.
10. Narayanan, A.; Kaur, S.; Peng, C.; Debnath, D.; Mishra, K.; Liu, Q.; Dhinojwala, A.; Joy, A. Viscosity Attunes the Adhesion of Bioinspired Low Modulus Polyesters to Wet Tissues. Biomacromolecules 2019, 20, 2577-2586
Degradable tissue adhesives that prevent hemorrhage of internal organs are created. Interestingly, a strong correlation between the viscosity and tissue adhesion was derived. Low viscosity and hydrophobicity were found to be key to stick on to tissue surfaces submerged in blood plasma.
Degradable tissue adhesives that prevent hemorrhage of internal organs are created. Interestingly, a strong correlation between the viscosity and tissue adhesion was derived. Low viscosity and hydrophobicity were found to be key to stick on to tissue surfaces submerged in blood plasma.
9. Liu, Q.; Yuan, S.; Guo, Y.; Narayanan, A.; Peng, C.; Wang, S.; Miyoshi, T.; Joy, A. Modulating the Crystallinity, Mechanical Properties, and Degradability of Poly (𝛆-caprolactone) Derived Polyesters by Statistical and Alternating Copolymerization. Polym. Chem. 2019, 10, 2579-2588.
With modular chemistry, the degradation and mechanical properties of poly(e-caprolactone)/PCL is tuned.
With modular chemistry, the degradation and mechanical properties of poly(e-caprolactone)/PCL is tuned.
8. Liu, Q.; Wang, C.; Guo, Y.; Peng,C.; Narayanan, A.; Kaur, S.; Xu, Y.; Weiss, R. A.; Joy, A. Opposing Effects of Side-Chain Flexibility and Hydrogen Bonding on the Thermal, Mechanical and Rheological Properties of Supramolecularly Crosslinked Polyesters. Macromolecules 2018, 51, 9294-9305.
Using the combination of synthesis and extensive rheological studies we prove that the side-chain flexibility can hinder the mechanical properties provided by supramolecular interactions.
Using the combination of synthesis and extensive rheological studies we prove that the side-chain flexibility can hinder the mechanical properties provided by supramolecular interactions.
7. Kaur, S.#; Narayanan, A.#; Dalvi, S.; Liu, Q.; Joy, A.; Dhinojwala, A. Direct Observation of the Interplay of Catechol Binding and Polymer Hydrophobicity in a Mussel-Inspired Elastomeric Adhesive. ACS Cent. Sci. 2018, 4, 1420-1429. #equally contributed
Combining adhesion and interface-sensitive spectroscopy measurements, we show the synergistic action of polymer hydrophobicity and catechol binding in underwater adhesion of mussel-inspired polymers.
Combining adhesion and interface-sensitive spectroscopy measurements, we show the synergistic action of polymer hydrophobicity and catechol binding in underwater adhesion of mussel-inspired polymers.
6. Xu, Y.; Liu, Q.; Narayanan, A.; Jain, D.; Dhinojwala, A.; Joy, A. Mussel-Inspired Polyesters with Aliphatic Pendant Groups Demonstrate the Importance of Hydrophobicity in Underwater Adhesion. Adv. Mater. Interfaces 2017, 4, 1700506 (1-6).
We created a bioinspired degradable soft hydrophobic polymer which can stick strongly underwater as good as it sticks under dry conditions.
Documented by the show 'Nature Knows Best' Season 2, Episode 10 (Medicine) available at Amazon Prime and Hulu
Highlighted by insiderscience.org 'Flow Like an Oil, Stick Like a Mussel'
We created a bioinspired degradable soft hydrophobic polymer which can stick strongly underwater as good as it sticks under dry conditions.
Documented by the show 'Nature Knows Best' Season 2, Episode 10 (Medicine) available at Amazon Prime and Hulu
Highlighted by insiderscience.org 'Flow Like an Oil, Stick Like a Mussel'
Publications from Undergraduate School
5. Bauri, K.; Pan, A.; Haldar, U.; Narayanan, A.; De, P. Exploring Amino Acid-Tethered Polymethacrylates as CO2-Sensitive Macromolecules: A Concealed Property. J. Polym. Sci. A. Polym. Chem. 2016, 54, 2794-2803.
Created acrylic polymers derived from natural amino acids using RAFT polymerization. The polymers displayed carbon dioxide encapsulation and self-assembled upon CO2 purge.
Created acrylic polymers derived from natural amino acids using RAFT polymerization. The polymers displayed carbon dioxide encapsulation and self-assembled upon CO2 purge.
4. Narayanan, A.; Chandel, S.; Ghosh, N.; De, P. Visualizing Phase Transition Behavior of Dilute Stimuli Responsive Polymer Solutions via Mueller Matrix Polarimetry. Anal. Chem. 2015, 87, 9120-9125.
The stimuli responsive behavior of PNIPAM was characterized using home-built Mueller matrix polarimetry. The concentration dependent stimuli responsiveness has been studied. For the first time, the concentration dependence of cloud point was decoupled.
The stimuli responsive behavior of PNIPAM was characterized using home-built Mueller matrix polarimetry. The concentration dependent stimuli responsiveness has been studied. For the first time, the concentration dependence of cloud point was decoupled.
3. Bauri, K.; Narayanan, A.; Haldar, U.; De, P. Polymerization-Induced Self-Assembly Driving Chiral Nanostructured Materials. Polym. Chem. 2015, 6, 6152-6162.
Alcoholic RAFT dispersion polymerization was performed to create versatile library of functional self-assembled structures such as micelles, worm-like micelles, vesicles and etc.
Alcoholic RAFT dispersion polymerization was performed to create versatile library of functional self-assembled structures such as micelles, worm-like micelles, vesicles and etc.
2. Narayanan, A.; Maity, B.; De, P. Exploring the Post-Polymerization Modification of Side-Chain Amino Acid Containing Polymers via Michael Addition Reactions. React. Funct. Polym. 2015, 91, 35-42. Highlighted as most downloaded article from June-Aug 2015.
Post-polymerization functionalization of amine pendant polymethacrylates were performed using Aza-Michael addition
Post-polymerization functionalization of amine pendant polymethacrylates were performed using Aza-Michael addition
1. Narayanan, A.; Bauri, K.; Ruidas, B.; Pradhan, G.; Banerjee, S.; De, P. Specific Counterion Repercussion on the Thermal, pH-response and Electrochemical Properties of the Side-Chain Leucine Based Chiral Polyelectrolytes. Langmuir 2014, 30, 13430−13437.
The physical chemistry of polyelectrolytes in bulk and solution was studied as a function of counterion shielding. The effect of sterics and molecular interactions are documented.
The physical chemistry of polyelectrolytes in bulk and solution was studied as a function of counterion shielding. The effect of sterics and molecular interactions are documented.
Patent Applications
1. Abraham Joy, Amal Narayanan, Tanmay Jain, Russell Catania, Nicholas Nun. Methods and Devices that Change Color to Indicate the Presence of Opioids and Other Narcotics, International Patent Serial No: WO2020/04174A1
2. Abraham Joy, Amal Narayanan. Non-Ionic Coacervates for Dry, Humid and Wet Adhesion, United States Patent Serial No: US 11033573 B1
3. Abraham Joy, Amal Narayanan, Kaushik Mishra. Preparation of Catechol Containing Polymer Emulsion and Their Deprotection and Post-polymerization. United States Provisional Patent
4. Abraham Joy, Apoorva Vishwakarma, Amal Narayanan. Use of Polymer Coacervates for the Disruption and Removal of Biofilms. United States Provisional Patent.
2. Abraham Joy, Amal Narayanan. Non-Ionic Coacervates for Dry, Humid and Wet Adhesion, United States Patent Serial No: US 11033573 B1
3. Abraham Joy, Amal Narayanan, Kaushik Mishra. Preparation of Catechol Containing Polymer Emulsion and Their Deprotection and Post-polymerization. United States Provisional Patent
4. Abraham Joy, Apoorva Vishwakarma, Amal Narayanan. Use of Polymer Coacervates for the Disruption and Removal of Biofilms. United States Provisional Patent.
